|
|
|
|
|
|
|
|
|
|
제목 |
한국에서 발견된 한센병 환자의 유전자 다형성에 따른 나균 유형 |
|
|
|
|
|
저자 |
김종필, 조상래 |
소속 |
한국한센복지협회, 연세의대 미생물학교실 |
|
|
|
년도 |
2007 |
권 |
1 |
|
|
|
호 |
40 |
번호 |
1 |
|
|
|
시작페이지 |
3 |
끝페이지 |
24 |
|
|
|
첨부 |
김종필, 조상래.pdf |
|
|
|
요약 |
Recently, PCR-based typing would be of great value for Epidemiological investigation to identify infectious source of leprosy, understand transmission pattern, and distinguish between relapse & re-infection. Variable TTC DNA repeats in non-coding region and 6bp(GACATC) tandem repeats in rpoT gene revealed PCR products of different size may be useful to investigate the epidemiology of leprosy.
Authors have typed clinical isolates of M. leprae in Korea using difference of TTC DNA repeats in non-coding region and 6bp(ACATCG) tandem repeats in rpoT gene. Of the sequence analysis of isolates(M. leprae) of 52 patients(44 Koreans, 8 foreigners; Bangladesh, Indonesia, Philippine, Sri Lanka, Thailand)
M. leprae with 12 TTC repeats was showed most common(13 cases, 29.5%) in 44 Korean isolates and 42 Koreans(95.5% of Korean isolates) isolates demonstrated four copies of 6bp(ACATCG) tandem repeats in rpoT gene and the isolates with three copies were found in 2 Koreans and 8 foreigners.
Key Words Genotyping, leprosy, M. leprae, rpoT, TTC repeats
|
|
|
|
내용 |
|
 | |
| |
|
|
|
|
|
|
|
|
|
