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제목 |
The Lepromin Reaction |
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저자 |
Hong Sik Kim |
소속 |
Department of Dermatology, College of Medicine, Seoul National University |
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년도 |
1967 |
권 |
4 |
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호 |
1 |
번호 |
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시작페이지 |
9 |
끝페이지 |
11 |
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첨부 |
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요약 |
The lepromin reaction was described at first by Mitsuda in 1919. He discovered that
boiled emulsion of lepromatous tissue rich in lepra bacilli induces a nodular reaction a
few weeks after intracutaneous injection.
The role of lepromin test is different from those of the tuberculin reaction. The
lepromin shows strong positive result not only in healthy contact persons. According to
the recent studies, a specific antigen produced by acid-fast bacilli from soil and other
sources.
A positive correlation between lepromin and tuberculin sensitivities has been described
by several writers.
The early(Fernandez) reaction is a response to a sensitivity already established in the
patient, either by previous experience wish M. Leprae or through cross-sensitivity
resultting from contact with other. Mycobacterium, eg. M. Tuberculosis. The
late(Mitsuda) reaction is a evidence of resistance or immunity to M. Leprae resulting
from antigen-antibody reaction. Reading of reaction:
1. Erythema and induration‥‥‥developing 24-48 hours after injection, remaining for
3-5 days. (Fernandea early reaction)
2. Late reaction‥‥‥develops 3-4 weeks after the injection, often termed the Mitsuda
reaction.
Kinds of Lepromin antigen:
1. Integral lopromits (L. I.)
2. Bacilillary lepromin (L. B.)
3. Purified leprodin protein(L. P. P.) |
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내용 |
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