|
|
|
|
|
|
|
|
|
|
제목 |
HLA Phenotypes in Korean Lepromatous Leprosy Patients |
|
|
|
|
|
저자 |
Tai Ho Chung, Nan Hee Kim, and Joon Young Song |
소속 |
Kungpook University, School of Medicine, Biomedical Research Institution, The Leprosy Mission, Jesus Hospital, Department of Dermatology, Keimyung University, School of Medicine |
|
|
|
년도 |
1993 |
권 |
26 |
|
|
|
호 |
2 |
번호 |
|
|
|
|
시작페이지 |
9 |
끝페이지 |
22 |
|
|
|
첨부 |
|
|
|
|
요약 |
The incidence of leprosy in Korea has been steadily declining, but it is not yet
uncommon in general population. Socioeconomic and environmental factors have long
been known to influence the development of leprosy in a community. Multiple drug
therapies against lepropy have been exploited but the disease process is not well
controlled despite of regular chemotherapy.
And only a small fraction of all infected individuals eventually develop leprosy and
may develop into specific types of leprosy. These suggest that genetic factors, especially
the HLA system, may play an important role in the development of leprosy and the
determination of types of leprosy, The present study was undertaken to investigate the
proposal that HLA phenotyes in leprosy patients are linked with the genes conferring
susceptibility to leprosy and predisposing to a particular leprosy type. We performed
HLA typing in 30 Korean lepromatous leprosy patients and 30 healthy controls. The
typing of HLA-A, B, C was performed by two-stage lymphocytotoxicity technique and
of HLA-DR and DQ was by PCR method.
Of 11 HLA-A phenotypes observed in our study, HLA-A33 frequency was
significantly increased (p<0.05) in patients over the control group. At HLA-B locus, only
HLA-B55 was significantly (p<0.01) decreased in patients. Results for the HLA-C locus
showed and increased gene frequency of the C4 (p<0.05) in patients over those in the
control group. The phenotype and gene frequency for the HLA-DR and DQ,
corresponding P values and relative risks are summarized in the Tables 4 and 5. There
was a significant increase in the gene frequencies of HLA-DRl4 (p<0.01), DQwl
(p<0.001), and DQw4 (p<0.01) in patients over those in the control group. |
|
|
|
내용 |
|
 | |
| |
|
|
|
|
|
|
|
|
|
