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제목 |
A Study on Susceptibility and Subclinical Infection of M. leprae in Contacts of Leprosy Patients |
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저자 |
Koo Weon Jeong, Ee Seok Lim, Ki Hye Kim, Yong Ma Hah |
소속 |
Korean Leprosy Control Association |
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년도 |
1992 |
권 |
25 |
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호 |
2 |
번호 |
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시작페이지 |
42 |
끝페이지 |
56 |
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첨부 |
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요약 |
Lepromin test from 739 leprosy contacts(male 349, female 390) have been studied by
household and non-household contact, sex and age. The serological activities of the
specific phenolic glycolipid-Ⅰ from Nycobacterium leprae were examined by
ELISA(enzyme linked immunosorbent assay) using ND-O-BSA against sera from 350
contacts of leprosy patients.
The results obtained were summerized as follows :
1. 2.4% of all 739 contacts of leprosy patients were shown lepromin negative which is
considered high-risk population among contacts.
2. Mitsuda negative cases were shown more in non-household contacts (3.4%) than in
household contacts(1.9%). It is considered that close and frequent contacts give more
high immunity than less contacts.
3. In comparison with Mitsuda reaction by sex, 2.8% of female contacts showed
negative while 2.0% of male showed negative.
By age, Mitsuda negative cases were shown 2.3% in under 20 age group, 2.5% in
21-40 age group and 1.7% in over 41 age group.
4. Among the 350 contacts of leprosy patients, 43(12.3%) revealed positive anti-PGL-1
IgM in their sera.
5. 5 of 263 non-household leprosy contacts showed positive antibody titers(positive
rate : 7%), and 28 of 476 household leprosy contacts showed positive results(positive
rate : 21%). It was interesting to note that family/household contacts showed a higher
rate of seropositivity than non-household contacts. This difference may again reflect an
influence of genetic factors associated with increased susceptibility in family/household
contacts as compared to non-household contacts. Percent seropositivity in family
contacts by the type of leprosy of the index case was 5.3% (1/19) in contacts of
paucibacillary and 24.6% (14/57) in contacts of multibacillary cases. The antibody level
may reflect the intensity of exposure, with higher levels induced by repeated exposure.
6. The seropositivity by lepromin test was 25% (1/4) in contacts with a negative, 0%
(0/2) in contacts with doubtful(±), 32% (8/25) in contacts with one-plus positive(+),
13%(7/54) in contacts with two-plus positive (++) and 19% (5/26) in contacts with
three-plus positive(+++) Mitsuda reaction. |
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내용 |
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