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제목 |
The Change Of Tissue Phenolic Glycolipid 1 Levels In Frozen Skin Lesions Frost 43 Leprosy Patients Following The Chemotherapy |
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저자 |
Koo Weon Jeong |
소속 |
Korea Leprosy Control Association Anyang, Korea |
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년도 |
1991 |
권 |
24 |
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호 |
1 |
번호 |
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시작페이지 |
33 |
끝페이지 |
43 |
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첨부 |
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요약 |
Phenolic glycolipid 1(PGL-1) is a Mycobacterium leprae-specific antigen and has been
used widely for the serodiagnosis of leprosy. The change of tissue phenolic glycolipid 1
levels in frozen skin lesions from 43 leprosy patients(31 new, 11 relapse and 1 reaction)
was examined with PGL-1 and Anti-PGL-1 levels in sera following the chemotheraspy
to compare the different responses to bacterial load in tissue and sera. Among the 43
patients, 39(91%) had detectable PGL-1 in frozen skin tissue. Of the 4 cases with
negative PGL-1 two showed BI 4+, one was 813+ and one
was BI 1+. When patients with PGL-1 in tissue were monitored
throughout the chemotherapy, PGL-1 titer declined lowly comparing with PGL-1 in sera.
PGL-1 in frozen skin tissue was stronger than sera. This study revealed dearly that
PGL-1 in frozen skin tissue might be the reliable parameter to monitor of leprosy to the
chemotherapy. |
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내용 |
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