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제목 |
A STUDY ON MOUSE FOOT-PAD TESTS FOR DDS AND RMP SENSITIVITY OF M. LEPRAE IN NEW AND RELAPSED LEPROMATOUS PATIENTS |
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저자 |
Koo Weon Jeong, Young Hoon Ko, Do Il Kim |
소속 |
Institute for Leprosy Research Korean Leprosy Control Association |
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년도 |
1990 |
권 |
23 |
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호 |
1 |
번호 |
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시작페이지 |
41 |
끝페이지 |
47 |
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첨부 |
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요약 |
The mouse footpad sensitivity tests were studied in 46 new patients with previously
untreated lepromatous leprosy and 21 relapsed lepromatous leprosy patients. The biopsied
skin was homogenized for the preparation of suspensions of Mycobacterium leprae for
the inoculation of hind footpads of mice. The inoculated mice were divided into six
groups. One group was observed as control and the other groups received DDS and
RMP incorporated in different concentrations in their diets such as 0.01%, 0.001% and
0.0001% DDS and 0.04% and 0.004% RMP in the diet.
The following results were observed.
1 Primary D-R rate was 10(22%) among 46 previously untreated lepromatous patients.
Of the 10 primary D-R cases, six showed high degree of resistance(0.01% DDS diet),
one was moderate resistance (0.001% DDS diet) and three was low resistance(0.0001%,
DDS diet).
2. Secondary D-R rate was 14(67%) among 21 relapsed lepromatous patients. Of the 14
secondary D-R cases, nine showed high resistance, four moderate resistance and one
low resistance.
3. So far, the results of 15 mouse footpad tests to RMP were available ; 10 from
newly diagnosed patients and 5 from relapse cases. Among the former, three showed
RMP resistance (low degree 0.004% RMP diet). Among the latter, no RMP-resistant
stains were detected. |
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내용 |
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