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제목 |
A DETECTION OF ANTIBODIES AGAINST PHENOLIC GLYCOLIPID - I OF M.LEPRAE AMONG LEPROSY PATIENTS AND CONTACTS BY ELISA |
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저자 |
Koo Weon Jeong |
소속 |
Korean Leprosy Control Association Anyang, Korea |
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년도 |
1988 |
권 |
21 |
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호 |
1 |
번호 |
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시작페이지 |
11 |
끝페이지 |
24 |
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첨부 |
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요약 |
The serological activities of the specific phenolic glycolipid - I from Mycobacterium
leprae were examined by ELISA (enzyme-linked immunosorbent array) using
ND-O-BSA against sera from 404 patients with leprosy, 81 contacts and 118 normal
persons as control group.
The results obtained were summerized as follows:
1. The mean absorbance and positive rate of anti-PGL-I IgM was 0.556 (68%) in
multi-bacillary, 0.231 (39%) in paucibacillary leprosy patients,0.119 (11%) in contacts and
0.035 (3%) in normal control persons and the highest in multibacillary group.
2. The seroreactivity to PGL-I in new (0.547) and relapse (0.498) of leprosy patients
was slight higher compared with that (0.369) of old cases.
3. There was a correlation between the results of anti-PGL-I IgM and bacterial index.
4. Anti-PGL-I IgM decreased rapidly in 1-2 years of treatment.
5. Among immunoglobulin classes tested, however IgM was the major anti-PGL-I
antibody clam present in sera from leprosy patients, there was a clear evidence that
only IgG was prominent particularly in patients with long-term therapy. |
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내용 |
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