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제목 |
Purine Nucleoside Phosphorylase Activities in Erythrocytes of Leprosy Patients |
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저자 |
Mi Soon Park, Seung Churl Lee, Inn Ki Chun, Young Pio Kim |
소속 |
Dept. of Dermatology, Chonnam University Medicine School Kwangju, Korea |
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년도 |
1987 |
권 |
20 |
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호 |
1 |
번호 |
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시작페이지 |
53 |
끝페이지 |
56 |
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첨부 |
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요약 |
Purine nucleoside phosphorylase(PNPase) is an enzyme, which catalyzes the conversion
of purine nucleoside to the free purine base and found in most human tissues. A role
for PNPase in the immune response has been suggester by the findings that the enzyme
is deficient in the T-cell immunity.
Leprosy is an infectious disease caused by Mycobacterium leprae and divided into two
polar forms.
The present study was designed to measure the activity of PNPase in erythrocytes of
blood from patients with lepromatous and tuberculoid leprosy and from normal subjects.
The erythrocyte PNPase activities of lepromatous leprosy patients were with (2.08±
0.98 units/107 cells, n=10) significantly lower than those of tuberculoid
leprosy patients (3.80±1.96 units/107 cells, n=10) as well as of normal
subjects (5.04±0.16 units/107 cells, n=20).
From the results, it is suggested that the enzyme may participate in the cell-mediated
immunity and demonstrated biochemically that lepromatous leprosy is considered to be
manifested in persons with deficient cell-mediated immunity. |
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내용 |
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