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제목 |
T Lymphocyte Subsets in the Skin Lesions of Patients with Leprosy |
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저자 |
Kyung Sool Kwon#, Tae Ahn Chung#, Tetszi Mitsui## |
소속 |
Dept. of Dermatology, College of Medicine, Pusan National University, Pusan, Korea# and Dept. of Pathology, School of Medicine, Fukuoka University, Fukuka, Japan## |
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년도 |
1987 |
권 |
20 |
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호 |
1 |
번호 |
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시작페이지 |
33 |
끝페이지 |
39 |
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첨부 |
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요약 |
Lymphocyte subsets in the tissues of 13 fresh patients with various kinds of leprosy
were studied using monoclonal antibodies and a modified immunoperoxidase (ABC)
technique.
There was a higher percentage of Leu 4 positive cells from tuberculoid to lepromatous
end of the spectrum. The number of T helper/inducer cells were greater in
paucibacillary leprosy than those of multibacillary leprosy, and T suppressor/cytotoxic
cells were the reverse. Characteristically T helper/inducer cells in paucibacillary form
were predominantly in the mantle surrounding the peripheral nerves and T
suppressor/cytotoxic cells scattered in and around the granuloma. In multibacillary form,
the T helper/inducer and T suppressor/cytotoxic cells were both distributed among the
granuloma.
OKT 6 positive epidermal Langerhans cells were identified greater number in
tuberculoid and borderline specimens than in lepromatous specimens, by contrast, very
few number of anti-S-100 positive cells were demonstrated in both multibacillary and
paucibacillary forms. Twenty to thirty percent of B lymphocytes were found in only 2
cases of paucibacillary form and one case of borderline lepromatous leprosy. Small
and/or none of NK cells were present in both multibacillary and paucibacillary forms
without any differences.
The results reported here indicate that this technique adds valuable information about
the local immune response and classification of patients with leprosy. |
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내용 |
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