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제목 |
A STUDY ON RIFAMPICIN- RESISTANCE THROUGH MOUSE FOOTPAD TESTING |
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저자 |
Koo Weon Jeong, Young Hoon Ko, Do Il Kim |
소속 |
Institute for Leprosy Research Korean Lerprosy Control Assciation |
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년도 |
1986 |
권 |
19 |
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호 |
1 |
번호 |
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시작페이지 |
63 |
끝페이지 |
68 |
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첨부 |
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요약 |
In one new patient with previously untreated lepromatous leprosy and two relapsed
lepromatous leprosy patients, the mouse footpad sensitivity tests were studied. The
biopsies shin was homogennized for the preparation of suspensions of Mycobacterium
leprae for the inoculation of hind footpads of mice. The inoculated mice were divided
into six groups. One group ached as a control and the other group received DDS and
RMP incorporated in different concentrations in their diet, such as 0.01%, 0.001% and
0.0001% DDS and 0.03% and 0.004% RMP in the diet. The following results were
observed.
1. After nodule biopsy from active new lepromatous leprosy patient who was tested
as Bacterial Index 4.1+ and Morphological Index 1.7% was stored in freezer (-18∼-20℃)
for 71 days, this specimen was inoculated in mouse footpad, but resulted by no bacterial
growth in even control group.
2. Mouse footpad tests were revealed as high DDS-resistant and RMP-sensitive
bacterial growth in two relapsed lepromatous leprosy patients.
3. The highest rate of bacilli increase was shown in the harvest of nine months (270
days) after inoculation. |
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내용 |
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