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제목 |
Immunohistochemical Study of Lysozyme in Macrophages of Leprosy |
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저자 |
Kyung Sool Kwon, Tae Ahn Chung |
소속 |
Dept. of Dermatology, College of Medicine, Pusan National University Pusan, Korea |
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년도 |
1986 |
권 |
19 |
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호 |
1 |
번호 |
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시작페이지 |
51 |
끝페이지 |
61 |
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첨부 |
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요약 |
A peroxidase-antiperoxidase study using rabbit antihuman lysozyme (muramidase) was
undertaken in order to determine whether a lysozyme activity of macrophages is present
in leprosy, since such enzymes have been postulated to play in part bacteriolytic action
in leprosy.
The results were as follows:
1. Of 13 patiens with lepromatous leprosy, 8 patients showed negative activity for
lysozyme except one patient and 5 patients associated with erythema nodosum leprosum
showed two- to three-plus activity for lysozyme.
2. Of 5 patients with borderline lepromatous leprosy, 3 patients showed negative and 2
patients showed one-plus activity for lysozyme.
3. All 3 patients with borderline leprosy showed negative activity for lysozyme.
4. All 5 patients with borderline tuberculoid leprosy showed two- to three-plus
activity for lysozyme.
5. All 3 patients with tuberculoid leprosy showed three-plus activity for lysozyme.
6. Of 9 patients with relapsed leprosy, 5 patients with relapsed borderline tuberculoid
leprosy showed two- to three-plus, one patient with relapsed borderline leprosy was
two-plus, and 3 patients with relapsed borderline lepromatous leprosy were negative
activity for lysozyme.
These results suggest that the lysozyme activity of macrophage may reflect the
degree of immunity in leprosy patients since the lysozyme activity generally is positive
in tuberculoid pole, reversal and erythema nodosum leprosum reactions, and negative in
lepromatous pole and downgrading reactions. |
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내용 |
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