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제목 |
Comparative Trial of Rifampicin Alone and Rifampicin Plus Dapsone(DDS) in the Treatment of Lepromatous Leprosy |
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저자 |
Shi Ryoun Choi(최시룡), Kyoung Ju Lee(이경주), Donald W. Marion |
소속 |
Chronic Disease Laboratory, Catholic Medical College, Seoul, Korea |
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년도 |
1978 |
권 |
11 |
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호 |
1 |
번호 |
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시작페이지 |
87 |
끝페이지 |
90 |
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첨부 |
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요약 |
Our study didn't find any significant difference between combination therapy
(rifampicin+dapsone) and monotherapy (rifampicin) according to decrease in B.I., M.I.,
ENL occurrence, or improvement in clinical features. Rapid decrease in M.I. was
observed in all patients, and all cases had reached baseline M.I. within 15 months of
therapy. Although some cases showed an increase in B.1. before the ninth or tenth
month of treatment(four patients in the groups receiving combination therapy), all
patients had a markedly reduced B.I. after 18 months of treatment, and 7 of the 15
cases had converted from B.I. positive to negative. ENL occurred during treatment in
four patients, but did not involve a concurrent rise in B.I. or M.I., and after 18 months,
no patient was in ENL. Paripheral clinical features were markedly improved after a year
of therapy, but nerve thickening showed only mild improvement, or no improvement in
some cases. This may be due to the presence of "persister organisms", or could simply
be due to the characteristic of nerve tissue to collagenize in the presence of fragmented
bacili. We conclude that rifampicin, whether in combination with dapsone or by itself, is
much more effective than sulfone therapy in eradication of M. leprae. |
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내용 |
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