|
|
|
|
|
|
|
|
|
|
제목 |
Incidence of Hepatit is B Antigen Positivity Among Leprosy Patients in Korea |
|
|
|
|
|
저자 |
Choi, S. R., Chung, W. K.#, Lee, C. M.## |
소속 |
Chronic Disease Laboratory, Dept. of Internal Medicine#, and Dept. of Clinical Laboratory## Catholic Medical College |
|
|
|
년도 |
1976 |
권 |
10 |
|
|
|
호 |
1 |
번호 |
|
|
|
|
시작페이지 |
53 |
끝페이지 |
61 |
|
|
|
첨부 |
|
|
|
|
요약 |
Sera from 80 leprosy patients were tested for hepatitis B surface antigen (HBsAg),
using solid please double-antibody radioimmunoassay technique (RIA) and for serum
glutamicoxalacetic-transaminase (SGOT) and serum glutamic
pyruvic-transaminase(SGPT) by Karmen method. As a control, sera from 41 medical
and nursing students for HBsAg, and l,595 blood donors from the blood bank of Catholic
Medical Center for SGOT and SGPT were also tested.
The leprosy patients were selected from the out-patients of Chronic Disease
Laboratory in Seoul and resettled patients who were discharged from leprosy hospitals,
living in Kyonggi-do province. A skin biopsy was taken from each of the patients, and
histological diagnosis was established. 55 were of a lepromatous type, 11 were of a
tuberculoid tripe and 14 were a borderline group of patients.
The following results were obtained :
1. In the leprosy patients, the frequency of HBsAg was 8.8% which is a slightly
lower than in the control group(9.8%). The abnormal elevations of SGOT and SGPT
were observed in 4.1% and 3.4% of the control group and in 10.0% and 9.8% of the
laprosypatients respetcively. The frequency of abnormal elevations of SGOT and SGPT
activities was significantly higher in the leprosy patients than in the control group.
(P<0.05).
2. The type of disease had no correlation with the incidence of HBsAg. The frequency
of SGPT elevation was only 14.5% in the lepromatous type of patients. The frequency
of HBsAg was higher in the patients who were bacteriologically negative than in those
who were bacteriologically positive. The frequency of abnormal elevations of SGOT and
SGPT were bacteriologically positive.
3. Comparing males and females, the incidence of HBsAg was 13.7% in male patients
only, and no difference was noticed with regard to SGOT, SGRT between males and
females. In the patients in their third and forth decade, the incidence of HBsAg was
higher than in thosebevond the age of the fifth decade. There are no significant
difference between the age and SGOT, SGff elevations.
4. Correlation of the duration of illness and the incidence of HBsAg was not
remarkable. However, the abnormal elevations of SGOT and SGPT increased with the
duration of disease. The incidence of HBsAg was higher in the resettled patients(14.8%)
than in the out-patients (5.7%). Also, the abnormal SGOT and SGPT elevations were
higher in the resettled patients than in the out-patients.
5. The inccidence of HBsAg as well as the abnormal elevations of SGOT and SGPT
increased with the term of treatment. The incidence of HBsAg was also higher in the
patients with arenteral medication than in those with oral medication. The abnormal
elevation of SGPT was observed in the patients with oral medication. |
|
|
|
내용 |
|
 | |
| |
|
|
|
|
|
|
|
|
|
