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제목 |
Effect of Anti-macrophage Serum (AMS) and Anti-lymphocyte Serum (ALS) on Antibody Production and Murine Leprosy Infection in the Korean Chipmunks |
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저자 |
Kim, Joon Kul, Kim, Joo Deuk |
소속 |
Dept. of Microbiology Yonsei University College of Medicine, Seoul, Korea |
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년도 |
1976 |
권 |
10 |
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호 |
1 |
번호 |
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시작페이지 |
21 |
끝페이지 |
33 |
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첨부 |
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요약 |
Heterologous antisera to different cells knave been successfully used for a variety of
purposes for many years. Antisera against polrmorphonuclear leukocytes, mast cells,
lymphocytes and macrophages have been used in recent years to elucidate the roles of
these cells in various host responses. Anti-macrophage serum (AMS) and
anti-lymphocrte serum (ALS) depress a variety of immune responses. Unanue prepared
AMS and evaluated the properties and possible use of AMS, and there after AMS has
been widely used for studying the role of macrophages in immunological responses of
host. Unanue, Loewi et al, and Gallily et al reported that AMS could be cytotoxic
against peritoneal macrophages and inhibited the phagocytic activity of peritoneal
macrophages, but was not effective for immunosuppression.
However, many investigators made observation that AMS could depress the antibody
formation and prolong the skin allograft.
Though immunosuppressive effect of AMS are still controversial, the
immunosuppressive effect of ALS, especially in cell-mediated immune responses, has
been rather well established, and widelr applied in the animal experiments and human
organ transplantation.
Haman leprosy is caused by Mycobacterium leprae but the organism has never been
grown in vitro and only since 1960 the infection has been transmitted to a few animals.
Unfortunately, the experimental infection of Mycobacterium leprae into the foot pads of
mice and infection in other rodents was mild and remained limited and the lesion was
microscopic.
To substitute this limited infections of Mycobcterium leprae in mice, efforts have been
made to develope more susceptible experimental animals and other immunosupermission
methods in order to increase the susceptibility of host animals to ,mycobacterium leprae.
Lew et al reported that the Korean chipmunks were susceptible to Mycobacterium leprae
and could be used as an experimental animal for leprosy study.
More recently it has been shown that the limiting factor has an immunological basis,
for a progressive and spreading infection can be produced in mice with a reduced
immunological capacity. These findings led to a surge of interest in the use of
immunosupressive agents for the transmission of experimental leprosy in animals.
However, several immunosuppresants, such as cortison and suramin, which have been
shown to enhance significantly the infection with other species of Mycotacteria, failed to
enhance leprosy in mice.
The present experiments were undertaken in order to define the inlmunosuppressive
effect of AMS and ALS on antibody formation and the enhancing effect of AMS and
ALS on murine leprosy infection in Korean chipmunks. |
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내용 |
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