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제목 |
Report of Congress Committees - Committee 1: Advances in Experimental Leprosy |
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저자 |
R.J.W.Rees, C.H. Binford, J.Covit, W.F. Kirchheimer, Y. Matsuo, S.R. Pattyn, G.M. Rivas, C.C. Shepard, E.E. Storrs, and A.G.M. Weddell |
소속 |
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년도 |
1975 |
권 |
9 |
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호 |
1 |
번호 |
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시작페이지 |
85 |
끝페이지 |
114 |
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첨부 |
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요약 |
This report covers the five clears since the last International Leprosy Congress.
However, before reviewing these advances and their relevance to leprosy in man, it is
necessary to consider, on the one hand, the contributions made from studies on
experimental models in the successful fight against other infectious diseases and, on the
other hand, the particular difficulties in developing any experimental models for studying
leprosy. In no field of medicine has greater progress been made than with the infectious
diseases, particularly those caused by bacteria but also some viruses. This progress in
knowledge, whether on the microbiologic, pathologic, preventive or therapeutic side, has
evolved, in the first instance, from studies on the cultivation and in vitro properties of
the causative organism and only subsequently on experimental animal models.
Unfortunately, leprosy has remained an exception, because Mycobacterium leprae has
still not been cultured in vitro and only since 1960 has an animal model been assailable.
Therefore, once animal models were assailable for studying leprosy it was reasonable to
assume that they would also be applicable to leprosy in man. In the first instance, the
mouse foot pad infection was systematically exploited and has enabled the same topics
to be studied in leprosy as in other bacterial diseases affecting man. However, the
mouse model had also to be adapted for studying the bacteriological characteristics of
M. leprae, which for other bacteria are studies in vitro.
From these general and particular considerations the field of experimental leprosy has
been developed and has rapidly advanced, all within the last thirteen years, almost
entirely based on animal models using the mouse and mode recently, the rat and the
nine-banded armadillo. Our report summarizes the relevance, importance and suitability
of these animal models in contributing to knowledge of leprose in man. |
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