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제목 |
Studios on chemoprophylaxis of leprosy with DDS |
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저자 |
Joon Lew, young Soo Kim |
소속 |
Dept. of Microbiology Yonsei University College of Medicine and World Vision Special Skin Clinic |
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년도 |
1975 |
권 |
9 |
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호 |
1 |
번호 |
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시작페이지 |
75 |
끝페이지 |
84 |
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첨부 |
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요약 |
Since G.A. Hansen (1874) discovered M. leprae from leprosy tissue, it has been
accepted that leprosy is a chronic contageous disease, and occurs chiefly among poorer
people in poverty striven countries. In the treatment of leprosy, although chaulmoogra oil
had been used from ancient times, it has now been abandoned. Faget et al. (1943)
introduced promin, one of the derivatives of DDS, in the chemotherapy of leprosy and
since then many investigators have been interested in chemotherapeutic agents for
leprosy. Cochrane et al. (1949). Loweand Smith (1949), and Lowe (1950) reported that
DDS is more potentially active against mycobacteria than promin, and it has been
acceptcd that DDS is the drug of choice in the treatment of leprosy.
However, DDS has still many limitations in the treatment of leprosy. Davey (1964)
pointed out its rather strong toxicity, precipitation of hypersensitivity and prolonged
period of medication. Therefore, many investigators haute attempted to find an ideal
chemotherapeutic agent for leprosy (Buu-Hoi et al, 1955; Schneider et at, 1958; Davey &
Hogerzeil, 1959; Lew et at, 1968).
Many leprosy workers believe that leprosy control will be provided not only by
effective treatment, but also by effective prophylactic measures.
Fernandez (1939) suggested the possibility of leprosy prevention with BCG vaccination.
Numerous clinical and field trials have been carried out in the attempt to prove the
effectiyeness of BCG vaccination both as a stimulant for lepromin positive conversion,
and as a prophylactic measure against leprosy (Azulay, 1949: Convict et at, 1952: Souza
Campos, 1953: Brown et at, 1968; Bechelli et al, 1968).
As chemoprophylactic agents, chloroquine has been used for malaria (Bolding, 1960),
penicillin for syphilis (Andrew & Domonkos, 1963), and INH for tuberculosis (Payne,
1957; WHO, 1965). Leprosy is also a chronic disease and has a long incubation period.
The idea is to eliminate the causative agent in the host tissue or to interfere with the
host parasite relationship during its incubation period by the administration of DDS as a
chemoprophylactic measure in leprosy contacts.
The possibility of chemopjophylaxis of leprosy with DDS has been suggested and
reported by some leprosy workers (Lee & Lew, 1960; Lew & Kim, 1966; Dharmendra et
at, 1967).
The purpose of this study is to prove the effective chemoprophylactic vague of DDS
against leprosy contacts and to analyze she epidemiologic factors in leprosy families. |
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내용 |
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